DISTINCT TARGET GENES AND EFFECTOR PROCESSES APPEAR TO BE CRITICAL FOR P53-ACTIVATED RESPONSES TO ACUTE DNA DAMAGE VERSUS P53-MEDIATED TUMOUR SUPPRESSION

The p53 tumour suppressor is the most frequently mutated gene in human cancer.This transcription factor can be activated by diverse cellular stresses, including DNA damage and oncogene activation.Through transcriptional induction of appropriate target genes, p53 can stimulate activity in a broad range of effector pathways, most notably cell cycle a

Abstract Background Renal cell carcinoma (RCC) has multiple symptoms stemming from disease and treatments.There are few validated scales for evaluating RCC symptoms.Methods A national cross-sectional study of adult RCC patients was conducted from October to December 2003 to define patient-reported RCC symptomology.Participants were asked open-ended

In 2001, a new type of human ferritin was identified by searching for homologous sequences to H-ferritin in the human genome.After the demonstration that this ferritin is located specifically in the mitochondrion, it was called mitochondrial ferritin.Studies on the properties of this new type of ferritin have been limited by its very high homology

This week I forced myself to see 6.5" Speakers the film "Black Hawk Down" which is based on the October 1993 incident in Somalia in which 19 American soldiers and a 1000 Somalis were killed.Soon after this incident U.S.military forces left the country and the United Nations took over the watchdog function in the area.It was a difficult film to watc